Table 1.

Major Groups of Epigenetic Regulators

Epigenetic features	Regulator	Gene family
DNA methylation	Writer	DNA methyltransferases (DNMTs)
	Reader	5-methylcytosine-binding domain proteins (MeCP2 and MBDs)
	Eraser	Ten-eleven translocation dioxygenases (TETs), ALKBH1
Histone modifications	Writer	Lysine methyltransferases (KMTs), protein arginine methyltransferases (PRMTs), lysine acetyltransferases (KATs or HATs), histone ubiquitin ligases, histone kinases, and others
	Reader	Chromodomain, Tudor domain, MBT domain, PhD finger, bromodomain-containing proteins
	Eraser	Lysine demethylases (KDMs), histone deacetylases (HDACs and SIRTs), histone deubiquitinating enzymes, histone phosphatases, and others
Chromatin structure	Remodeler	SWI/SNF, ISWI, CHD, and INO80/SWR complexes