DNA methylation |
Writer |
DNA methyltransferases (DNMTs) |
Reader |
5-methylcytosine-binding domain proteins (MeCP2 and MBDs) |
Eraser |
Ten-eleven translocation dioxygenases (TETs), ALKBH1 |
Histone modifications |
Writer |
Lysine methyltransferases (KMTs), protein arginine methyltransferases (PRMTs), lysine acetyltransferases (KATs or HATs), histone ubiquitin ligases, histone kinases, and others |
Reader |
Chromodomain, Tudor domain, MBT domain, PhD finger, bromodomain-containing proteins |
Eraser |
Lysine demethylases (KDMs), histone deacetylases (HDACs and SIRTs), histone deubiquitinating enzymes, histone phosphatases, and others |
Chromatin structure |
Remodeler |
SWI/SNF, ISWI, CHD, and INO80/SWR complexes |