DNMT inhibitor |
DNA methylation writers |
Azacitidine (myelodysplastic syndromes), decitabine (myelodysplastic syndromes), procainamide (cardiac arrhythmias), hydralazine (essential hypertension), procaine (local anesthetics) |
Tioguanine, FdCyd, TdCyd, Aza-TdCyd, fluorocyclopentenylcytosine, guadecitabine |
HDAC inhibitor |
Histone acetylation erasers |
Vorinostat (cutaneous T cell lymphoma), romidepsin (cutaneous T cell lymphoma), belinostat (peripheral T cell lymphoma), panobinostat (multiple myeloma), valproic acid (seizures), chidamide (peripheral T-cell lymphoma, by CFDA) |
Tacedinaline, mocetinostat, abexinostat, entinostat, pracinostat, resminostat, givinostat, quisinostat, kevetrin, tefinostat, nanatinostat, domatinostat, ricolinostat, ME-344, CG200745, CUDC-101, AR42 |
KMT6A inhibitor |
Histone methylation writer |
Tazemetostat (epithelioid sarcoma) |
SHR2554, CPI-1205, GSK2816126, PF-06821497, MAK683 |
SIRT activator |
Histone acetylation erasers |
None |
SRT2104 |
BET inhibitor |
Histone acetylation readers |
None |
Mivebresib, molibresib, birabresib, INCB057643, ZEN003694, FT-1101, GSK2820151, CC-90010, CPI-0610, PLX51107, ABBV-744, BAY1238097, BI 894999, BMS-986158, GS-5829 |
PRMT5 inhibitor |
Histone methylation writer |
None |
JNJ-64619178, PF-06939999, GSK3326595 |
PRMT1 inhibitor |
Histone methylation writer |
None |
GSK3368715 |
KDM1A inhibitor |
Histone methylation eraser |
None |
Seclidemstat, IMG-7289, tranylcypromine, GSK2879552, INCB059872, phenelzine sulfate |
KMT4 inhibitor |
Histone methylation writer |
None |
Pinometostat |