Table 3. Univariable analysis for predictors of grade 4 lymphopenia and absolute lymphocyte nadir.

Parameter	Grade 4 lymphopenia			ALC Nadir
	OR (95% CI)	P value		Log transformed predictors (95% CI)	P value
Age	1.02 (0.94–1.08)	0.5		0.97 (0.90–1.002)	0.51
BMI	1.09 (0.98–1.25)	0.12		0.98 (0.98–1.005)	0.2
Sex (male)	1.2 (0.24–6.78)	0.82		0.93 (0.83–1.05)	0.39
Distal location	2.88 (0.3–43)	0.18		0.87 (0.72–0.92)	0.03
3DCRT	1.07 (0.31–3.65)	0.9		1.02 (0.93–1.1)	0.6
Diabetes	2.8 (0.85–10)	0.23		0.92 (0.83–1.001)	0.067
CAD	0.41 (0.08–1.7)	0.25		1.03 (0.94–1.14)	0.58
Adenocarcinoma histology	1.40 (0.35–6.1)	0.63		0.94 (0.86–1.0)	0.453
VVert10cc	1.01 (0.99–1.01)	0.051		0.997 (0.995–0.997)	0.004
VVert20cc	1.01 (1.001–1.015)	0.03		0.995 (0.993–0.998)	0.007
VVert30cc	1.01 (1.001–1.01)	0.012		0.996 (0.993–0.998)	0.038
VVert40cc	1.01 (0.98–1.039)	0.27		0.989 (0.97–1.01)	0.12
SV5cc	1.01 (0.99–1.02)	0.28		0.999 (0.997–1.01)	0.6
SV10cc	0.99 (0.98–1)	0.4		1.00 (0.99–1.02)	0.8
SV15cc	1.01 (0.99–1.02)	0.4		0.99 (0.998–1.00)	0.058
SV20cc	1.06 (0.98–1.03)	0.6		0.998 (0.994–1.00)	0.08
SV25cc	1.01 (0.98–1.05)	0.60		0.997 (0.91–1.00)	0.1
SV30cc	1.03 (0.98–1.08)	0.24		0.993 (0.98–1.00)	0.09
Mean spleen dose	1.00 (0.99–1.00)	0.40		0.998 (0.997–0.999)	0.0325
Mean vertebral body dose	1.01 (0.99–1.02)	0.37		0.996 (0.991–0.999)	0.0163
Mean thoracic dose	1.00 (0.90–1.02)	0.32		1.00 (0.99–1.00)	0.3
Mean body dose	1.03 (0.90–1.07)	0.10		0.997 (0.995–1.00)	0.115
Induction chemotherapy	0.64 (0.08–3.6)	0.63		0.90 (0.86–1.1)	0.7
Neoadjuvant CRT	0.55 (0.17–1.6)	0.29		0.90 (0.85–1.08)	0.89
Emergency room visits during CRT	1.96 (0.48–8.8)	0.35		0.94 (0.85–1.04)	0.3
Chemo held cycles*	2.62 (0.8–8.88)	0.1		0.88 (0.81–0.97)	0.009

*, in this case, held cycles was treated as the dependent variable.