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. 2020 May;12(5):2039–2048. doi: 10.21037/jtd-19-4206

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2020 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The effect of DACT2 on the ion channel protein mRNA level and Wnt signaling pathway in mouse atrial muscle cells. (A and B) Establishment of the DACT2-overexpressing cell line by using HL-1 cells; The expression levels of KCNE family proteins (C to F), KCNH2 (G), KCNJ5 (H), KCNQ1 (I), CACNA1C (J), CACNB2 (K), SCN5A (L). (M) The regulation of DACT2 on the Wnt and TGF-β signaling pathways in HL-1 cells. The experiment was repeated at least three times. Representative graphs are provided. *, P≤0.05; **, P≤0.01.