Figure 1.

Classification of concurrent genomic alterations in EGFR-mutated NSCLC. (A) Most frequently co-occurring pathways altered in EGFR-mutated NSCLC are highlighted in the pie chart (not necessarily mutually exclusive), which can impact the efficacy of EGFR-targeted therapy. (B) A pathway-centric classification of tumor genomic co-alterations could guide the selection of combination therapy approaches (118). (C) Real-time monitoring of tumor clonal evolution through liquid biopsies in conjunction with mathematical modeling may inform combination therapy treatment schedules and switching strategies (hypothetical clonal evolution shown) (119). EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TF, transcription factors.