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Changes in the systemic inflammatory markers. Fibrinogen, CRP, IL-6, TNF-α, and IL-33, in clockwise order. V1, visit 1 (baseline); V2, visit 2 (week 12); CRP, C-reactive protein; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α; IL-33, interleukin-33.
