Figure 8.

Overexpression of miR-4500 Inhibits the Expression of RRM2 to Inhibit Activation of the MAPK Signaling Pathway

(A) The protein expressions of p-ERK/t-ERK, p-p38/t-p38 and p-MEK/t-MEK detected by Western blot. (B) Comparison of relative protein expression of p-ERK/t-ERK, p-p38/t-p38, and p-MEK/t-MEK in each group. *, #, and &p < 0.05 versus the mimic NC group, si-NC group, and si-RRM2 group, respectively. The data comparisons were analyzed by one-way ANOVA, and the experiment was repeated three times independently.