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. 2020 May 4;21:278–289. doi: 10.1016/j.omtn.2020.04.018

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Overexpression of miR-4500 Downregulates RRM2 to Inhibit Breast Cancer Growth In Vivo

(A) The growth of tumor volume in nude mice of each group after transfection and inoculation. (B) The tumor volume in vivo in each group detected by nude mice tumor xenograft assay. *, #, and &p < 0.05 versus the mimic NC group, si-NC group, and si-RRM2 group, respectively. The experiment was repeated three times independently, and data comparison at different time points in the figure was analyzed with repeated-measures ANOVA.