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Annotated Klotho variants (n = 1,090) using Gencode, version 19 with variant effect prediction, version 85 from the Genome Aggregation Database (gnomAD). This database spans 123,136 exomes and 15,496 genomes from unrelated individuals sequenced as part of various international disease-specific and population genetic projects, including the 1,000 genomes, Alzheimer’s Disease Sequencing Project, Atrial Fibrillation Genetics Consortium, T2D-SEARCH, and the Cancer Genome Atlas.
