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. 2020 Jun 25;11:1440. doi: 10.3389/fmicb.2020.01440

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Copyright © 2020 Yi, Li, Pang, Wang, Zhang, Duan, Liang and Cen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superimposition of complex structures of DENV-RdRp/JF-31-MG46 (PDB ID 5F3T) and hNV-RpRp/PPNDS (PDB ID 4LQ3). N-pocket inhibitor JF-31-MG46 and B-site ligand PPNDS are shown as cyan and magenta stick representation, respectively. The priming loop in DENV RdRp and C-terminal in hNV RdRp are highlighted in cyan and magenta loops, respectively. DENV and hNV RdRps share an overall structural architecture with fingers (blue), palm (yellow), and thumb domains (red).