. Author manuscript; available in PMC: 2020 Jul 2.

Published in final edited form as: Handb Exp Pharmacol. 2019;251:3–36. doi: 10.1007/164_2018_168

Table 1.

Depot-specific developmental origins of BAT

Tissue Type	Anatomical Locations (Human)	Anatomical Locations (Mouse)	Developmental Origins (Lineage Tracing Study)
Brown adipocyte	Supraclavicular/Paravertebral Perivasicular: (aorta, artery) Periviscus: (heart, lung bronchia) Solid organs: kidney/spleen hilum pancreas, liver	Interscapular	En1⁺, Myf5⁺, Pax7⁺, Pax3⁺, Prx1⁻
		Subscapular	En1⁻, Myf5⁺, Pax7⁺, Pax3⁺, Prx1⁻
		Cervical	En1^?, Myf5^+/−, Pax7⁺, Pax3^+/−, Prx1⁻
		Peri-renal	En1^?, Myf5⁻, Pax7⁺, Pax3^+/−, Prx1⁻
		Peri-aortic	En1^?, Myf5⁻, Pax7⁺, Pax3⁻, Prx1^+/−
Brite/beige adipocyte	Supraclavicular/Subcutaneous	Posterior-Subcutaneous (Inguinal)	En1^?, Myf5⁻, Pax3⁻, Prx1⁺