Table 2.
| Class | Subtype | Protein domain | Number of amino acids | Protein size (kDa) | Localization | Yeast homolog |
|---|---|---|---|---|---|---|
| Ⅰ | HDAC1 |  |
482 | 58 | Nucleus | RPD3 |
| HDAC2 |  |
488 | 59 | Nucleus | ||
| HDAC3 |  |
428 | 50 | Nucleus, cytoplasm | ||
| HDAC8 |  |
377 | 44 | Nucleus | ||
| Ⅱa | HDAC4 |  |
1,084 | 120 | Nucleus, cytoplasm | Hda1 |
| HDAC5 |  |
1,122 | 130 | Nucleus, cytoplasm | ||
| HDAC7 |  |
912 | 110 | Nucleus, cytoplasm | ||
| HDAC9 |  |
1,011 | 160 | Nucleus, cytoplasm | ||
| Ⅱb | HDAC6 |  |
1,215 | 160 | Nucleus, cytoplasm | |
| HDAC10 |  |
669 | 70 | Nucleus, cytoplasm | ||
| Ⅲ | Sirt1 |  |
747 | 120 | Nucleus | Sir2 |
| Sirt2 |  |
389 | 45 | Cytoplasm | ||
| Sirt3 |  |
399 | 28 | Mitochondria | ||
| Sirt4 |  |
314 | 35 | Mitochondria | ||
| Sirt5 |  |
310 | 36 | Mitochondria | ||
| Sirt6 |  |
355 | 39 | Nucleus | ||
| Sirt7 |  |
400 | 48 | Nucleus | ||
| Ⅳ | HDAC11 |  |
347 | 39 | Nucleus | HOS3 |
Catalytic domain 
MEF-binding domain