Table 1.

Clinical characteristics of patients and healthy controls

Variables	Circulating exosome sample						Tissue sample
	Discovery cohort (NGS)		Validation cohort (RT-qPCR)			Advanced-stage
	LA-pre & -post	HCs	LA-pre	LA-post	HCs	LA-pre & -post
Total number	7	7	56	51	40	8	8
Gender (Male/ Female)	4/3	4/3	20/36	18/33	12/28	4/4	3/5
Age (year, mean ± SD)	55.1±7.3	56±1.5	57.4±9.4	57.6±9.0	59.7±8.0	59.3±10.3	65.9±7.0
Clinical stage
IA/IB	7	7	56	51	—	—	6
IIIA	—	—	—	—	—	8	2