Table 2.
Hepatic features in WD patients with or without cirrhosis
| Cirrhosis (n = 119) | Non-cirrhosis (n = 53) | P-value | |
|---|---|---|---|
| Liver function features | |||
| ALT (U/L) | 22.00 (15.00-34.00) | 23.00 (14.00-55.50) | 0.508 |
| AST (U/L) | 23.00 (18.00-38.00) | 23.00 (18.00-38.90) | 0.797 |
| Albumin (g/L) | 39.00 (36.00-41.10) | 40.00 (36.65-44.00) | 0.044 |
| PT (s) | 14.40 (13.60-15.30) | 13.50 (12.95-14.25) | <0.001 |
| INR | 1.12 (1.04-1.21) | 1.03 (0.97-1.10) | <0.001 |
| Total cholesterol (mmol/L) | 3.67 (3.06-4.45) (n = 88) | 3.98 (3.65-4.66) (n = 40) | 0.054 |
| Triglyceride (mmol/L) | 0.82 (0.62-1.06) (n = 88) | 0.98 (0.81-1.32) (n = 40) | 0.010 |
| Bilirubin (μmol/L) | 13.30 (9.10-18.10) | 11.10 (7.75-13.75) | 0.010 |
| Hepatic encephalopathy | 1 (0.84) | 0 (0) | 1.000 |
| Kayser-Fleischer ring | 39 (32.77) | 13 (24.53) | 0.277 |
| Child-Pugh classification | 0.225 | ||
| A | 113 (94.96) | 53 (100) | |
| B/C | 6 (5.04) | 0 (0) | |
| Portal hypertension features | |||
| Portal vein diameter (mm) | 10.00 (10.00-11.00) (n = 88) | 9.00 (8.00-10.00) (n = 40) | <0.001 |
| Ascites | 3 (2.52) | 1 (1.89) | 1.000 |
| Splenomegaly/splenectomy | 76 (63.87) | 15 (28.30) | <0.001 |
| Hematocytopenia | |||
| WBC (109/L) | 4.60 (3.38-5.75) | 5.04 (4.43-6.50) | 0.012 |
| RBC (1012/L) | 4.37 (3.93-4.83) | 4.61 (4.14-4.96) | 0.021 |
| Platelet (109/L) | 170.96 ± 89.59 | 227.49 ± 93.00 | <0.001 |
| Leukopenia | 39 (33.05) | 9 (16.98) | 0.031 |
| Erythropenia | 16 (13.56) | 5 (9.43) | 0.447 |
| Thrombocytopenia | 35 (29.66) | 3 (5.66) | <0.001 |
Data are presented as means ± standard deviation, medians (interquartile ranges) or n (%). ALT, alanine transaminase; AST, aspartate transaminase; INR, international normalized ration; PT, prothrombin time; RBC, red blood cell; WBC, white blood cell; WD, Wilson disease.