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. 2020 Jun 15;11(16):4899–4906. doi: 10.7150/jca.45548

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Plasma exosome-derived miR-139-3p levels at different colorectal cancer stages. (A) Exosomal miR-139-3p expression levels in plasma were significantly down-regulated in CRC patients when compared with healthy controls (B) No statistical differences were observed in plasma exosomal miR-139-3p levels between stages T1 + T2 and T3 + T4 patients. (C) Exosomal miR-139-3p expression levels in plasma were significantly down-regulated in metastatic colorectal cancer (mCRC) patients when compared with non-metastatic colorectal cancer (non-mCRC) patients.