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. 2020 May 25;11(16):4724–4735. doi: 10.7150/jca.33232

Figure 5.

Figure 5

Exosomes miR-410-3p promotes metastasis of CRC cells in vivo. (A) Representative images of lung or liver metastasis in nude mice that resulted from HT29 cells alone or HT29 cells treated with hypoxic (with or without GW4869) or normoxic exosomes or HT29 cells transfected with miR-410-3p mimics/NC (B) Percentage of mice with metastasis is indicated from HT29 cells alone or HT29 cells treated with hypoxic (with or without GW4869) or normoxic exosomes or HT29 cells transfected with miR-410-3p mimics/NC (n=6 per group). (C) Weight of nude mice was monitored every 5 days after being injected with HT29 cells alone or HT29 cells treated with hypoxic (with or without GW4869) or normoxic exosomes or HT29 cells transfected with miR-410-3p mimics/NC via the tail veins. (D) Schematic model of hypoxic exosomal miR-410-3p promoting CRC progression. CRC cells-derived exosomal miR-410-3p under hypoxia mediates tumor progression via PTEN/PI3K/Akt signaling pathway, which facilitates the migration, invasion, and metastatic potential of CRC cells. Error bars, SD. *P<0.05.