Figure 1.

Representation of some of the metabolic adaptation and reprogramming of cancer stem cells. In the interconnected metabolic pathways of glucose, the key junctions are glycolysis and pentose phosphate pathway and central molecules are Glucose-6-phosphate, Pyruvate and Acetyl-CoA. In proliferative state cells metabolized Glucose mainly through PPP and perform less glycolysis and ATP has been produced from TCA cycle via respiratory electron-transfer chain by Acetyl-CoA coming either from pyruvate, Fatty acids and Amino acids oxidation. In Hypoxic condition PPP is inhibited and glucose metabolized through anaerobic glycolytic pathway. In presence of low glucose intermediate metabolites and ATP are produced mainly by glutaminolysis and fatty acids oxidation. CSCs synthesize fatty acids for membrane formation and oxidized this for energy production the equilibrium between anabolism and catabolism of fatty acids is maintain by NADPH and ATP requirement.