. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Biochim Biophys Acta Biomembr. 2020 May 3;1862(9):183329. doi: 10.1016/j.bbamem.2020.183329

Table 1:

Mouse genetic studies reveal important roles for desmosomal proteins in development and homeostasis.

Gene	Expression	Lethality	Observed Defects	References
*Dsg1*	Knockout	Perinatal Lethal	epidermal water loss, severe blistering	[124]
*Dsg2*	Knockout	Embryonic Lethal	Pre-implantation lethality, potentially non-desmosomal role	[125]
*Dsg2*	Suprabasal Epidermal Misexpression	Not Lethal	Hyperproliferation, abnormal differentiation, barrier defects	[28]
*Dsg3*	Knockout	Not Lethal	Separated keratinocytes, weakened desmosomal adhesion in oral mucosa	[126]
*Dsg3*	Suprabasal Epidermal Misexpression	Not Lethal	Hyperproliferation, abnormal differentiation, barrier defects	[127]
*Dsc1*	Knockout	Not Lethal	Epidermal hyperproliferation, loss of cell-cell adhesion	[128]
*Dsc3*	Knockout	Embryonic Lethal	Post-implantation lethality, potentially non-desmosomal role	[129]
	Epidermal Conditional	Not Lethal	Epidermal fragility, hair loss	[130]
	Suprabasal Epidermal Misexpression	Not Lethal	Hyperproliferation, abnormal differentiation, barrier defects	[123]
PG	Knockout	Embryonic Lethal	Heart defects, skin fragility	[131]
*Pkp1*	Knockout	Postnatal Lethality	Epidermal fragility, tight junction defects, growth defects	[132]
DP	Knockout	Embryonic Lethal	Die at E6.5	[133]
DP	Epidermal Conditional	Perinatal Lethal	Severe skin fragility, disrupted barrier function	[134]