Figure 2.

A. Membrane-anchoring PS for enhanced PDT. Self-assembly of chimeric peptides into nanoparticles and the charge reverse at tumor environment (left), resulting in cell membrane disruption and cell necrosis (right). Adapted with permission from ref. 53. Copyright 2017 Wiley-VCH. B. Intranuclear PS delivery and PS for enhanced PDT. (1) Schematic illustration of sequential-targeted PDT based on Ce6@MSNs-RGD/TAT. (2) Tumor growth curves of different groups of tumor-bearing mice after PDT. (3) Photographs of the mice taken after 0 day, 7 and 15 days of PDT. Adapted with permission from ref. 56. Copyright 2014 Wiley-VCH. C. Schematic representation of nanoplatforms and the directed attack of cancer cell lysosomes by NO and ROS under near infrared (NIR) light irradiation. Adapted with permission from ref. 66. Copyright 2016 Royal Society of Chemistry.