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. 2020 May 30;10(16):7100–7110. doi: 10.7150/thno.45939

Figure 4.

Figure 4

IL-1β induces PCSK9 secretion in mice. (A) Survival rate for different groups of mice fed standard diet (SD) or high fat diet (HFD-C). (B) and (C) Body weight and body fat of WT and IL-1β-/- mice given SD or HFD-C for 24 weeks. All mice were given recombinant IL-1β (D) Serum PCSK9 levels in WT and IL-1β-/- mice. Data represent the mean ± SD of several independent experiments (n=5 mice per genotype in cell experiments and n=7 mice per genotype in animal experiments), each performed in triplicate. **P<0.001, ***P<0.001, ****P<0.0001 vs. indicated group.