Figure 2.

miR-1291 reduces the tumor cell tumorigenicity. (A) The images of xenograft tumor-bearing mice and tumors derived from PANC-1 and MDA-MB-231 cells infected with retroviruses expressing either miR-1291 or control vector (n = 8). (B) Subcutaneous xenograft tumors arising from PANC-1 and MDA-MB-231 cells were monitored for 4 weeks and 3 weeks, respectively. Tumor weights of mice in both groups. Tumor sizes are presented as mean ± SD over time (n = 8). (C) Comparison of the ratio of dissected tumor weights over body weights of mice. Data are mean ± SD (n = 8). (D) IHC analysis was used to determine Ki67 levels in tumor samples. (E) Western blot assay were used to measure ERRα and CPT1C protein in tumor samples.