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. 2020 Jun 25;10:1080. doi: 10.3389/fonc.2020.01080

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Copyright © 2020 Kong, Yao, Ding, Dong, Wu, Sun and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IF1 in HCC cells indirectly and directly affected angiogenesis of TAECs after insufficient RFA. CM from HCC cells after IF1 knockdown or overexpression with or without insufficient RFA was collected. (A,B) Transwell assay analysis of TAECs migration after co-culture with CM from Hep3B and Huh7 cells. (C) The statistical results of (A,B) were shown. (D,E) Analysis of TAECs tube formation after co-culture with CM from Hep3B and Huh7 cells. (F) The statistical results of (D,E) were shown. (G,H) Hep3B or Huh7 cells (with GFP) were co-cultured with TAECs and VM was observed. (I) The statistical results of (G,H) were shown. (J) Western blot validation of the transfection efficiency in TAECs. (K) The matrigel plug assay containing TAECs-shRNA-IF1 and control was performed. Data are the means ± SD of at least three experiments. *P < 0.05, **P < 0.01, ***P < 0.001; ns, no significance.