Table 1.

Proteus’ results for the first case study (details were included in the supplementary material: Tables S2, S3, S4, S5). (1) β-glucosidase project is available at: http://proteus.dcc.ufmg.br/result/id/4L8HLU. (2) Protease project is available at: http://proteus.dcc.ufmg.br/result/id/N7Q9RZ. (3) Immunoglobulin new antigen receptor project is available at: http://proteus.dcc.ufmg.br/result/id/UM6SQD. (4) Lipase project is available at: http://proteus.dcc.ufmg.br/result/id/YTP3YC

#	Protein	PDB ID	ProteusID	Sequence length	Number of mutations suggested
1	β-glucosidase (hydrolase)	1BGA	4L8HLU	447	344
2	Protease	1LVB	N7Q9RZ	243	61
3	Immunoglobulin new antigen receptor	2YWY	UM6SQD	113	50
4	Lipase	1LGY	YTP3YC	269	213