Fig. 4.

KIF23 was up-regulated in PCa tissues and cell lines and targeted by miR-15a-5p. a, b The expression of KIF23 at mRNA and protein levels in PCa tissues and normal tissues was measured by qRT-PCR and western blot, respectively. c, d The expression of KIF23 at mRNA and protein levels in PCa cells and normal cells was measured by qRT-PCR and western blot, respectively. e The expression of miR-15a-5p was negatively correlated with KIF23 expression. f The binding sites between miR-15a-5p and KIF23 3′ UTR were forecasted by starBase v2.0. g The interaction between miR-15a-5p and KIF23 was confirmed by dual-luciferase reporter assay. h, i The expression of KIF23 was modulated by miR-15a-5p expression at both mRNA and protein levels. *P < 0.05, **P < 0.01, ***P < 0.001