Table 3.

The association between clinicopathological characteristics and schistosomiasis in CRC cohort

Characteristic		All patients		P	Stage I–II disease patients		P	Stage III–IV disease patients		P	With lymph node metastasis patients		P	Without lymph node metastasis patients		P
		CRC-NS (N = 214)	CRC-S (N = 137)		CRC-NS (N = 116)	CRC-S (N = 76)		CRC-NS (N = 98)	CRC-S (N = 61)		CRC-NS (N = 88)	CRC-S (N = 56)		CRC-NS (N = 126)	CRC-S (N = 81)
Age (< 60 years)				< 0.001			< 0.001			< 0.001			< 0.001			< 0.001
< 60		78	5		41	5		37	0		34	0		44	5
≥ 60		136	132		75	71		61	61		54	56		82	76
Gender				0.467			0.695			0.520			< 0.001			0.588
Male		126	86		70	48		42	23		35	36		53	31
Female		88	51		46	28		56	38		53	20		73	50
Tumor site				0.274			0.750			0.829			0.806			0.030
Rectum		57	37		31	19		26	18		22	15		35	22
Left colon		64	51		29	31		35	19		33	18		31	33
Right colon		93	49		56	25		37	24		33	23		60	26
Tumor size				0.985			0.597			0.581			0.372			0.443
< 5 cm		106	68		55	39		51	29		46	25		60	43
≥ 5 cm		108	69		61	37		47	32		42	31		66	38
Differentiation				0.570			0.577			0.700			0.952			0.417
Well diff.		165	102		101	64		64	38		57	36		108	66
Poor diff.		49	35		15	12		34	23		31	20		18	15
Lymphovascular invasion				0.909			0.732			1.000			1.000			1.000
Negative		138	90		87	59		51	32		46	30		92	60
Positive		76	47		29	17		47	29		42	26		34	21
Nervous invasion				1.000			0.766			1.000			1.000			1.000
Negative		194	125		108	72		86	54		78	49		117	76
Positive		20	12		8	4		11	7		10	7		9	5
Lymph nodes positive for CRC				0.867			0.998			0.710			1.000			1.000
≤ 2		189	120		115	76		74	44		67	42		122	78
> 2		25	17		1	0		24	17		21	14		4	3
Colonic perforation				0.966			0.482			0.373			0.299			0.487
No		206	132		110	74		96	58		87	53		119	79
Yes		8	5		6	2		2	3		1	3		7	2
Tumor budding				0.652			0.184			0.454			0.841			0.393
< 5 cells		83	49		61	32		22	17		20	14		63	35
≥ 5 cells		131	88		55	44		76	44		68	42		63	46
Histological type				0.731			0.470			0.590			1.000			0.633
Adenocarcinoma		191	120		106	67		85	53		76	48		115	72
Mucinous/SRCC		23	17		10	9		13	8		12	8		11	9
Ulceration				0.740			0.881			0.774			0.495			1.000
No		125	77		69	44		56	33		51	29		74	48
Yes		89	60		47	32		42	28		37	27		52	33
Pathological T stage				0.562			0.395			0.891			0.749			0.388
T1–2	I + II	51	29		42	23		9	6		8	6		43	23
T3–4	III	163	108		74	53		89	55		80	50		83	58
Lymph node metastasis				0.883			0.823			0.641						–
No		126	81		114	75		12	6		0	0		–	–
Yes		88	56		2	1		86	55		88	56		–	–
TNM stage				0.816			–			–			0.842			0.379
I + II		116	76		–	–		–	–		2	1		112	75
III + IV		98	61		–	–		–	–		86	55		14	6

“–,” data is not applicable. Abbreviation: N number. The association between schistosomiasis and clinicopathological characteristics was evaluated by using the chi-square and Fisher’s exact tests