Skip to main content
. Author manuscript; available in PMC: 2020 Aug 11.
Published in final edited form as: Cell. 2019 Oct 31;179(4):964–983.e31. doi: 10.1016/j.cell.2019.10.007

Figure 4. Differential Expression of Transcriptomic and Proteomic Profiles between ccRCC Tumors and NAT Protein Expression.

Figure 4.

(A) PCA visualization of protein expression in ccRCC tumors and NATs.

(B) Analysis of significantly differentially regulated pathways (adjusted p < 0.05) between ccRCC tumors and NATs.

(C) Schema of metabolic pathways (glycolysis and electron transport chain [OXPHOS]) with select differential gene expression of mRNA and protein levels between ccRCC tumors and NATs.

(D) Scatterplots depicting expression of mRNA (x axis) and protein (y axis). Linear regression of all mRNA-protein pairs (gray dotted line) and OXPHOS mRNA-gene pairs (red dotted line) are shown. Metabolism-related genes are indicated.

(E) Boxplot of representative OXPHOS genes from complex I (NDUFV2), IV (COX6C), and V (ATP6V1F) displaying discordant mRNA-protein expression (n.s., not significant, *adjusted p < 0.05).

See also Figure S4 and Tables S1, S4, and S5.