Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 2;20:617. doi: 10.1186/s12885-020-07062-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Synergy interpretation. HT-29 and MCF-7 cells were seeded into a 96 well plate at a density of 1.5 (HT-29) and 0.5 × 10⁴/well (MCF-7), incubated 24 h to a confluency of 50%, then medicated with increasing concentrations of PRIMA-1met, YM155 and their combination for 48 h. Cell viability was assessed using the MTT-Assay and curve was further analysed using Graphpad Prism. CI-Values were calculated by CompuSyn and illustrated with red dots in the diagram on the right. Each dot corresponds to the respective combination shown in the graph to the left. CI-values underneath the dashed line (< 1) imply a synergism. Viability data were also illustrated in a bar-chart design at 0.125x (B) 0.25x (C), 1x (D) and 2x EC₅₀ (E)