Table 1.
Patient characteristics
| German chronic cohort (n = 147) |
US ALF cohort (n = 28) |
|
|---|---|---|
| Age at blood sample collection (years) | 35 (16–69) | 26 (15–57) |
| Female gender | 79 (54%) | 20 (71%) |
| ALT (U/L) | 36 (10–436) | 36 (7–1463) |
| AST (U/L) | 30 (8–580) | 188 (43–4481) |
| GGT (U/L) | 33 (5–471) | – |
| Bilirubin (mg/dL) | 0.7 (0.3–7.8) | 31.4 (4.5–67.6) |
| Albumin (g/L) | 44 (22–53) | 24 (16–28) |
| Urea (kU/L) | 6.1 (1.0–11.9) | – |
| Sodium (mmol/L) | – | 139 (131–149) |
| Creatinine (mg/dL) | 0.7 (0.4–2.4) | 1.2 (0.4–7.1) |
| WBC count (× 109/L) | 5.9 (2.5–12.8) | 13.4 (3.4–54.9) |
| INR | 1.1 (0.9–2.0) | 2.8 (1.7–6.5) |
| Phosphate (mmol/dL) | – | 2.9 (1.0–11.7) |
| Serum copper (μmol/L)† | 4.5 (0.1–29.9) | 0.3 (0.2–208.0) |
| Ceruloplasmin (g/L) | 0.10 (0.01–0.32) | 0.17 (0.04–0.45) |
| Urinary copper (μmol/day)†, ‡ | 2.5 (0.2–27.5) | 40,110.2 (661.4–9,931,842.2) |
ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, WBC white blood cell, INR international normalized ratio
Values are obtained at the same time as the blood samples used to measure soluble CD163
Data are medians (ranges) for continuous variables and total number (%) for categorical variables
†n = 17 in US ALF cohort
‡n = 108 in German chronic cohort