Table 3.
Response to bronchodilator administration
| 3a) MBW | |||||
|---|---|---|---|---|---|
| Value | Group | Pre‐bronchodilator | Post‐bronchodilator | Difference Pre and Post¶,* | P ¶ |
| LCI 2.5% | Healthy Controls | 7.63 (7.29,8.25) | 7.96 (7.41, 8.47) | 0.1 (−0.07, 0.76) | 0.05 |
| Asthmatics | 7.85 (7.42, 8.59) | 8.11 (7.52, 8.80) | 0.3 (−0.27, 0.57) | 0.14 | |
| LCI5.0% | Healthy Controls | 5.54 (5.19, 5.91) | 5.69 (5.38, 5.94) | 0.19 (−0.07, 0.39) | 0.05 |
| Asthmatics | 5.53 (5.36, 5.89) | 5.44 (5.20, 5.83) | −0.01 (−0.32, 0.35) | 1.00 | |
| FRC (L) | Healthy Controls | 0.85 (0.63, 1.01) | 0.87 (0.61, 1.01) | 0.02 (−0.06, 0.04) | 0.66 |
| Asthmatics | 0.78 (0.65, 0.95) | 0.89 (0.66, 1.03) | 0.04 (−0.03, 0.17) | 0.14 | |
|
LCI, lung clearance index; FRC, functional residual capacity. ¶There was no significant change in MBW parameters after bronchodilator administration for either Healthy Controls or Asthmatics *There were no differences between Healthy Controls and Asthmatics in any of the MBW tests | |||||
| 3b) FOT | |||||
|---|---|---|---|---|---|
| Value | Group | Pre‐bronchodilator | Post‐bronchodilator Difference Pre and Post¶,* | P ¶ | |
| R10 (hPa/L/sec) | Healthy Controls | 7.95 (7.00, 8.84) | 6.02 (5.43, 7.04) | −1.29 (−2.45, −1.02) | <0.0001 |
| Asthmatics | 7.83 (6.76, 9.32) | 6.46 (5.06, 6.97) | −1.46 (−1.99, −0.85) | <0.0001 | |
| R6‐R20 (hPa/L/sec) | Healthy Controls | 1.74 (0.97, 2.58) | 0.92 (0.35, 1.72) | −0.73 (−0.11, −1.56) | <0.0001 |
| Asthmatics | 2.42 (1.76, 3.39) | 0.82 (0.38, 1.52) | −1.41 (−1.09, −2.62) | <0.0001 | |
| X6 (hPa/L/sec) | Healthy Controls | −3.64 (−4.92, −2.91) | −2.74 (−3.42, −2.32) | 0.84 (1.64, 0.40) | <0.0001 |
| Asthmatics | −3.85 (−5.30, −2.77) | −2.35 (−3.61, 2.13) | 1.24 (1.95, 0.41) | <0.0001 | |
| X10 (hPa/L/sec) | Healthy Controls | −2.95 (−3.62, −2.00) | −1.77 (−2.12, −1.23) | 0.99 (0.59, 1.56) | <0.0001 |
| Asthmatics | −3.15 (−4.02, −2.39) | −1.73 (−2.08, −1.26) | 1.41 (1.09, 2.06) | <0.0001 | |
| f0 (Hz) | Healthy Controls | 25.21 (21.42, 28.90) | 20.51 (17.83, 22.36) | −4.69 (−7.34, −2.30) | <0.0001 |
| Asthmatics | 25.57 (22.23, 29.97) | 20.50 (18.62, 22.24) | −4.01 (−8.57, −1.31) | 0.0001 | |
| Rf0 (hPa/L/sec) | Healthy Controls | 6.73 (5.39, 7.60) | 5.34 (4.42, 6.60) | −0.91 (−1.67, −0.71) | <0.0001 |
| Asthmatics | 6.26 (5.46, 7.06) | 5.46 (4.10, 6.67) | −0.68 (−1.02, −0.34) | <0.0001 | |
| AX (cmH2O/L) | Healthy Controls | 37.07 (27.69, 54.54) | 23.61 (14.75, 27.24) | −13.8 (−26.8, −7.68) | <0.0001 |
| Asthmatics | 42.75 (28.36, 59.27) | 20.16 (14.51, 27.54) | −19.0 (−36.3, −11.9) | <0.0001 |
¶ There were significant changes in FOT parameters in both Healthy Controls and Asthmatics after bronchodilator administration.
* There were no significant differences in bronchodilator response between Healthy Controls and Asthmatics. The R6‐R20 bronchodilator response between asthmatics and controls came closest to significantly different, however (P = 0.058).