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. 2020 Jul 2;10:10949. doi: 10.1038/s41598-020-67941-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DAPT treatment inhibited cell apoptosis and attenuated elastin degradation in the lungs of mgR mice. (A–D) Lung tissue sections from DMSO (A, B) or DAPT (C, D) treated WT (A, C) and mgR (B, D) mice were immunostained with caspase3 (CC3) antibody. Quantitation of CC3⁺ cells is shown in bar graph on the right (E) (n = 4–5/group). #P < 0.05, *P < 0.001 compared to DMSO-treated mgR mice, ANOVA with Tukey–Kramer post hoc test. (F–I) VVG staining of elastic fiber in the lungs of WT (F, H) and mgR (G, I) mice treated with DMSO (F, G) or DAPT (H, I) (n = 5–10/group).