Table 4.

The parameter results of ROC curve analysis

	AUC (95% CI)	p valuea	Sensitivity (%) (95% CI)	Specificity (%) (95% CI)	Youden index	Cut-off value	p valueb	NRI
Prediction for total prognoses
NLR	0.69 (0.637–0.734)	<0.001	64.54 (0.583–0.706)	67.49 (0.606–0.739)	0.32	2.59	0.035	—
CRP	0.74 (0.695–0.786)	<0.001	61.48 (0.552–0.674)	78.17 (0.719–0.834)	0.39	10.85 mg/L	0.009	—
Prediction for severe progression
NLR	0.62 (0.565–0.681)	<0.001	54.19 (0.463–0.618)	67.49 (0.608–0.736)	0.22	2.60	0.343	—
CRP	0.67 (0.609–0.725)	<0.001	45.39 (0.377–0.533)	81.73 (0.757–0.865)	0.28	14.15 mg/L	0.646	—
Prediction for critical progression
NLR	0.77 (0.694–0.846)	<0.001	76.00 (0.618–0.869)	68.97 (0.621–0.753)	0.45	2.79	0.635	ref
CRP	0.84 (0.780–0.905)	<0.001	78.00 (0.645–0.872)	67.49 (0.608–0.735)	0.45	25.95 mg/L	0.134	15.52
Prediction for in-hospital death
NLR	0.81 (0.732–0.878)	<0.001	78.26 (0.637–0.891)	73.89 (0.673–0.798)	0.52	3.16	0.059	ref
CRP	0.89 (0.825–0.946)	<0.001	67.44 (0.525–0.7951)	0.929 (0.884–0.957)	0.60	33.40 mg/L	0.121	31.75
PCT	0.89 (0.835–0.962)	<0.001	73.81 (0.589–0.847)	93.62 (0.892–0.963)	0.67	0.85 ng/mL	<0.001	—

Abbreviations: AUC, area under the curve; CRP, C-reactive protein; NLR, neutrophil count/lymphocyte count ratio; NRI, net reclassification index.

^ap value for ROC curve.

^bp value for Hosmer–Lemeshow test.