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. 2020 Jul 2;10:10805. doi: 10.1038/s41598-020-67674-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Island tracking over time reveals variable increases in tumor size. Single MCF7 cells were cultured on collagen I islands, as described in Fig. 1 and resulting tumors were manually outlined (as shown in red) to measure their areas with Image J. a Bright-field images of three tumors (Islands 1, 2, 3) over time. Grape-like features on the tumor top and at the periphery are indicated by white arrows. b Temporal evolution of tumor area over 10 days for three biological replicates. Each solid dot represents the average area of 26 (in black), 48 (in red) and 47 (in blue) tumors with standard deviation. Inset shows the increasing trend in ratio of standard deviation to the average of tumor area for each experiment over time. c Images of tumors from another experiment that were maintained in culture for 21 days.