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. 2020 Jul 2;10:10805. doi: 10.1038/s41598-020-67674-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morphometry analysis reveals a positive correlation between tumor area and high average as well as heterogeneity in nuclear area. Single MCF7 cells were cultured on collagen I islands, as described in Fig. 1. At day 14 of culture, area and circularity of tumors and areas of nuclei were analyzed with ImageJ. Trendline and associated R-square for the fit are shown with high positive Pearson correlation (r ≥ 0.70, n = 6) between nuclear area and tumor area (a) and between tumor area and standard deviation [S.D.] in nuclear area (used as a measure of heterogeneity) (b). c and d Violin plots of nuclear area and circularity for each of the six tumors where 50–75 nuclei were analyzed per tumor.