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. 2020 Jul 2;10:10876. doi: 10.1038/s41598-020-67820-x

Table 4.

MIC of various antimicrobial agents in E. coli cells transformed with deduced RND-type efflux pump gene from K. pneumoniae.

Antimicrobial agent Minimum inhibitory concentration (μg/ml)
Host: E. coli KAM33 Host: E. coli KAM32
pSTV28 pKAC28M pKAB28 pKEF28 pKGH28 pKJK28 pKLM28 pKRS28 pKTU28 pKVWX28 pSTV28 pKC28 pKD28
vector acrAB oqxAB kexEF eefAB kexJK cusAB kexRS kexTU kexVWX vector kexC kexD
Oxacillin 8 1,024  > 1,024 256 256 8 8 8 8 32 16 512 n.t.
Cloxacillin 4 512 64 64 128 4 4 4 4 128 4 32 4
Norfloxacin 0.03 0.25 0.5 0.03 0.125 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03
Erythromycin 4 512 4 64 64 4 4 4 4 4 4 4 128
Kanamycin 1 1 1 1 1 1 1 1 1 1 1 1 1
Tetracycline 0.5 4 0.5 2 4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 2
Novobiocin 1 512 8 64 32 1 2 2 1 8 2 8 8
Acriflavine 8 128 64 16 128 8 8 8 8 16 2 2 8
Benzalkonium Cl 4 32 32 8 16 4 4 4 4 4 4 4 8
Hoechst33342 0.5 8 4 4  > 16 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1
Ethidium Br 4 1,024 128 128 1,024 4 4 4 4 4 4 4 32
Rhodamine 6G 8  > 1,024 512 256 1,024 8 8 8 8 8 8 8 32
SDS 64  > 1,024  > 1,024  > 1,024  > 1,024 512 64 64 64 64 64  > 1,024 256
TPPCl 8 1,024 512 256 1,024 8 8 8 8 8 8 8 256
Cholate 5,000  > 40,000 5,000 20,000 10,000 5,000 10,000 5,000 5,000 20,000 10,000 40,000 10,000

n.t. not tested.