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. 2020 Jun 25;13:85. doi: 10.3389/fnmol.2020.00085

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Copyright © 2020 O’Hare Doig, Santhakumar, Fehily, Raja, Solomon, Bartlett, Fitzgerald and Hodgetts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design. Following sham or spinal cord injury (SCI) surgery, two cohorts of animals (N = 28) were treated daily with butter (orally) or lomerizine (30 mg/kg, orally), and saline or oxATP + YM872 via osmotic mini-pump. Daily behavioral analyses were conducted for the first week following surgery, and then weekly thereafter. Surgical removal of pumps occurred in Cohort 2 animals, only. At 2 weeks (Cohort 1; n = 14) or 10 weeks following surgery (Cohort 2; n = 14), animals were humanely killed and tissue was harvested for analysis. *Total number of animals included in behavioral and histological analysis.