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. 2020 Jun 25;13:85. doi: 10.3389/fnmol.2020.00085

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Copyright © 2020 O’Hare Doig, Santhakumar, Fehily, Raja, Solomon, Bartlett, Fitzgerald and Hodgetts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean ± SEM locomotor function assessment (BBB) scores in the open field recovery assessment of hindlimb motor function, up to 10 weeks post-SCI. Animals treated with Lom, oxATP, and YM872 (dashed black line) compared to vehicle-treated control animals (solid black line; *p ≤ 0.05). Red dashed line represents a typical score of completely uninjured, normal animals (BBB = 21) and the green dashed line represents weight supporting BBB score (BBB = 9). No significant differences were observed between 2W and 10W cohorts (data not shown), therefore only 10W cohort shown (n = 6–7; n = animal numbers).