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. 2020 Jun 25;13:85. doi: 10.3389/fnmol.2020.00085

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Copyright © 2020 O’Hare Doig, Santhakumar, Fehily, Raja, Solomon, Bartlett, Fitzgerald and Hodgetts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Lom, oxATP, and YM872 on myelin basic protein (MBP) and oligodendroglia sub-populations, at 2W and 10W post-SCI. (A) Mean ± SEM intensity above the threshold, and (B) mean ± SEM area above the threshold of MBP (n = 6–7; *p ≤ 0.05). (C) Representative images show areas of MBP^+ve (magenta) immunoreactivity surrounding the injury site. White arrows demonstrate large area regions where MBP was not detected (scale = 50 μm). (D) Mean ± SEM mature oligodendrocytes cells per mm ² (n = 6–7; *p ≤ 0.05). (E) Representative images show the density of CC1^+ve NG2^−ve mature oligodendrocytes (green; indicated by white arrows) surrounding the injury site (scale = 25 μm). (F) Mean ± SEM OPCs per mm² (n = 6–7; *p ≤ 0.05). (G) Representative images show the density of NG2^+ve/PDGFα^+ve OPCs (green/red; indicated by white arrows) surrounding the injury site (scale = 25 μm; n = animal numbers).