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. 2020 Jul 2;10:10859. doi: 10.1038/s41598-020-67633-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative lung expansion analysis for a β-ENaC (M3, red) and littermate (M9, blue) pair of mice. (a) A histogram analysis of the fractional tissue displacement for the littermate and β-ENaC mice from Fig. 1, with the interquartile ranges of the normalised histogram shown as IQR. Note that Fig. 1 shows a single coronal slice, whereas the histogram is calculated from the entire volume. The fractional expansion for the β-ENaC mouse has a split peak. (b) The volume/time curve over the course of the ~ 0.5 s breath for the entire lung provides a global measurement of lung health. The volume of air breathed throughout the breath is expressed as a fraction of the entire lung volume; fractional volume. The healthy mouse breathes more air relative to the size of its lung. From this we can calculate the global expiratory time constant (τ).