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. 2020 Jul 2;10:10833. doi: 10.1038/s41598-020-67532-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypothermic neuroprotection. (a) Scatter plot of percent area loss in the NT (n = 305) and HT (n = 317) groups. The median with 95% CI is plotted adjacent to each scatter. Across the 21 experiments, median (95% CI) area loss in was 50.1% (46.0–51.9%; n = 305) in the NT group, and 41.3% (35.1–44.9%; n = 317) in the HT group. *Denotes significant neuroprotection (p < 0.001). (b) Cumulative frequency plot from the NT (n = 305) and HT (n = 317) groups, with each observation resulting in a proportional increase in the y-axis. A relatively uniform degree of neuroprotection is seen across the whole range of injury severity, particularly between 10 and 60% area loss.