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. 2020 Jul 2;10:10833. doi: 10.1038/s41598-020-67532-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Median difference in area loss between NT and HT. Median difference (with 95% CI) in area loss between the NT and HT groups in each individual experiment, and overall. Experiments are numbered in chronological order. Of the 21 experiments, 15 favoured HT, and the overall median difference (absolute reduction in area loss in the HT group) was 8.8% (3.4–14.2%).