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. 2020 Jul 2;10:10833. doi: 10.1038/s41598-020-67532-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global pathology scoring. (a) In the subset of animals that underwent formal pathology scoring (n = 277; n = 132 NT, n = 145 HT), median (95% CI) global pathology score 3.4 (3.3–3.7) in the NT group, and 2.4 (2.0–2.8) in the HT group. *Denotes significant neuroprotection (p < 0.001). (b) Cumulative frequency plot from the NT (n = 132) and HT (n = 145) groups, with each observation resulting in a proportional increase in the y-axis. A relatively uniform degree of neuroprotection is seen across the whole range of injury severity, with increasing relative neuroprotection in the HT group up to a global pathology score of 3.0.