Table 1.
Severity of injury and hypothermic neuroprotection.
| Exp | Date | Median percent area loss (95% CI) | Median difference | % Neuroprotection | Barometric pressure (mmHg) | |||
|---|---|---|---|---|---|---|---|---|
| NT | (N =) | HT | (N =) | |||||
| 1 | 10/01/2013 | 42.4 (28.2–51.4) | 16 | 44.4 (27.2–49.9) | 14 | − 2.0 | − 4.7 | 761 |
| 2 | 08/02/2013 | 29.8 (5.5–43.1) | 14 | 19.8 (2.5–26.9) | 14 | 10.0 | 33.5 | 763.5 |
| 3 | 18/03/2014 | 33.7 (9.8–50.5) | 11 | 47.6 (37.1–52.0) | 13 | − 13.9 | − 41.2 | 748.5 |
| 4 | 25/04/2014 | 10.6 (1.9–21.5) | 15 | 20.3 (2.3–22.9) | 15 | − 9.7 | − 92.4 | 769.6 |
| 5 | 15/05/2014 | 48.6 (26.4–58.1) | 11 | 27.9 (5.5–41.0) | 13 | 20.7 | 42.7 | 773.2 |
| 6 | 13/06/2014 | 45.2 (25.9–56.4) | 13 | 54.8 (36.7–58.7) | 14 | − 9.6 | − 21.3 | 760.7 |
| 7 | 14/08/2014 | 58.3 (29.5–62.8) | 10 | 37.2 (9.2–46.5) | 10 | 21.1 | 36.2 | 750.3 |
| 8 | 21/08/2014 | 58.7 (45.4–63.2) | 10 | 54.3 (6.0–59.8) | 10 | 4.4 | 7.5 | 751.1 |
| 9 | 28/08/2014 | 37.8 (5.2–52.2) | 12 | 24.1 (0.0–37.4) | 14 | 13.7 | 36.4 | 761.2 |
| 10 | 11/09/2014 | 53.8 (34.1–60.0) | 18 | 33.6 (15.2–39.5) | 18 | 20.2 | 37.5 | 767.6 |
| 11 | 23/10/2014 | 33.2 (6.7–45.1) | 12 | 23.2 (2.4–33.1) | 12 | 10.0 | 30.1 | 762.8 |
| 12 | 30/10/2014 | 36.6 (22.7–48.2) | 15 | 32.1 (21.3–40.6) | 17 | 4.5 | 12.4 | 766.1 |
| 13 | 28/11/2014 | 54.0 (33.8–58.7) | 12 | 46.2 (27.3–53.3) | 12 | 7.8 | 14.3 | 771.9 |
| 14 | 12/05/2015 | 43.0 (13.7–58.1) | 10 | 25.7 (0.8–28.7) | 12 | 17.3 | 40.2 | 755.4 |
| 15 | 18/06/2015 | 44.5 (27.2–51.0) | 17 | 34.4 (20.7–41.5) | 18 | 10.1 | 22.7 | 751.8 |
| 16 | 19/08/2015 | 27.7 (8.0–33.8) | 15 | 19.6 (4.2–27.3) | 17 | 8.1 | 29.4 | 770.4 |
| 17 | 27/08/2015 | 47.7 (28.8–56.4) | 16 | 46.9 (29.2–57.4) | 17 | 0.8 | 1.7 | 751.1 |
| 18 | 14/10/2015 | 39.0 (29.1–48.1) | 20 | 40.7 (27.7–48.1) | 22 | − 1.7 | − 4.4 | 773.4 |
| 19 | 12/11/2015 | 56.5 (38.9–59.3) | 22 | 39.0 (27.7–50.3) | 19 | 17.5 | 30.9 | 753.4 |
| 20 | 19/11/2015 | 50.3 (33.9–54.6) | 17 | 44.3 (27.7–50.6) | 18 | 6.0 | 11.8 | 743.5 |
| 21 | 07/01/2016 | 38.9 (23.2–43.0) | 19 | 42.0 (32.4–47.5) | 18 | − 3.1 | − 7.9 | 761.2 |
| Overall | 50.1 (46.0–51.9) | 305 | 41.3 (35.1–44.9) | 317 | 8.8 | 17.6 | ||
Median (95% CI) percent area loss in the NT and HT groups, and percent neuroprotection in the HT group, across all 21 experiments. The median difference in area loss between the two groups (median NT–median HT) was used to calculate percent neuroprotection in the HT group. Overall median area loss, median difference, and percent neuroprotection were calculated by combining all the animals in the NT (n = 305) and HT (n = 317) groups. The degree of neuroprotection provided by HT was not correlated with initial injury severity (median area loss in the NT group; Kendall’s τb, p = 0.83). As a potential factor associated with experimental variability, local barometric pressure on the morning of each experiment is also provided. Data from experiments 7–11 was previously published6.