Table 2. Analysis of the Association Between G6PC2 SNP rs560887 with Laboratory Analytes Using Electronic Health Record (EHR)-Derived Analyses.
Data show an association between G6PC2 SNP rs560887 and blood glucose, hemoglobin A1c (HbA1c) and blood taurine in either the total EHR population (All) or specific European American (EA) sub-populations. No associations were observed in the African American (AA) population or separately in AAs with or without T2D (data not shown). SE, standard error; FDR, false discovery rate. For each laboratory value, we tested for associations between the median of all lab values for an individual against the number of minor alleles for that individual. All associations were adjusted for covariates median age of record, sex, and EHR-reported race using linear regression. The units for all measurements in any given lab were consistent within the lab (e.g. all blood glucose values were reported in mg/dL).
| Gene | SNP | Population | Analyte | Effect Estimate | SE | OR | P | N | LCI | UCI | Bonferroni | FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G6PC2 | rs560887 | Total | GLUCOSE BLOOD | −0.05 | 0.01 | 0.95 | 6.56E-24 | 38301 | 0.94 | 0.96 | TRUE | TRUE |
| G6PC2 | rs560887 | Total | HGB A1C GLYCATED | −0.01 | 0.01 | 0.99 | 0.21060335 | 14328 | 0.97 | 1.01 | FALSE | FALSE |
| G6PC2 | rs560887 | Total | TAURINE | 0.32 | 0.08 | 1.38 | 7.28E-05 | 158 | 1.22 | 1.53 | TRUE | TRUE |
| G6PC2 | rs560887 | All EA | GLUCOSE BLOOD | −0.05 | 0.01 | 0.95 | 2.08E-22 | 32686 | 0.94 | 0.96 | TRUE | TRUE |
| G6PC2 | rs560887 | All EA | HGB A1C GLYCATED | −0.01 | 0.01 | 0.99 | 0.15780832 | 12271 | 0.97 | 1.00 | FALSE | FALSE |
| G6PC2 | rs560887 | All EA | TAURINE | 0.27 | 0.08 | 1.31 | 0.00171088 | 132 | 1.15 | 1.47 | FALSE | FALSE |
| G6PC2 | rs560887 | Non T2D EA | GLUCOSE BLOOD | −0.07 | 0.01 | 0.93 | 3.97E-38 | 21728 | 0.92 | 0.94 | TRUE | TRUE |
| G6PC2 | rs560887 | Non T2D EA | HGB A1C GLYCATED | −0.05 | 0.01 | 0.96 | 3.83E-05 | 4353 | 0.93 | 0.98 | TRUE | TRUE |
| G6PC2 | rs560887 | Non T2D EA | TAURINE | 0.29 | 0.09 | 1.34 | 0.00243233 | 114 | 1.16 | 1.53 | FALSE | FALSE |
| G6PC2 | rs560887 | T2D EA | GLUCOSE BLOOD | 0.01 | 0.01 | 1.01 | 0.18306124 | 6444 | 0.99 | 1.04 | FALSE | FALSE |
| G6PC2 | rs560887 | T2D EA | HGB A1C GLYCATED | 0.02 | 0.01 | 1.02 | 0.18513367 | 5159 | 0.99 | 1.04 | FALSE | FALSE |
| G6PC2 | rs560887 | T2D EA | TAURINE | 0.30 | 0.51 | 1.35 | 0.58240028 | 12 | 0.36 | 2.35 | FALSE | FALSE |