Figure 5.

Formation of detour circuits mediates functional recovery. (a) Experimental setup of the dorsal column lesion and re-lesion paradigm and behavioral testing. (b) Schematic of the “Placing test” and quantitative analysis of the scores obtained with the Placing test at 88 days following dorsal column lesion and following re-lesion experiments at spinal level C4 (p = 0.0248). (c) Schematic of the “Baton” test used to evaluate proprioception in mice and quantitative analysis of the scores obtained at the Baton test at 88 days following dorsal column lesion and following re-lesion experiments at spinal level C4 (p = 0.0047). (d) Paired scores obtained by individual mice 84 days following dorsal column lesion and re-lesion at C4 in the placing test (p = 0.0488). (e) Paired scores obtained by individual mice 88 days following dorsal column lesion and following re-lesion at C4 in the baton test (p = 0.002). Datasets were first tested for normality (non-normal distribution) and then analyzed using a Kruskall-Wallis test followed by post-hoc multiple comparison Dunn’s tests in (b) and (c) and using unparametric Wilcoxon paired tests in (d) and (e). “n” equals 12 in (d) and 13 in (e).