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. 2020 Jun 25;11:567. doi: 10.3389/fpsyt.2020.00567

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Copyright © 2020 Bokor, Krause, Torok, Eszlari, Sutori, Gal, Petschner, Anderson, Deakin, Bagdy, Juhasz and Gonda

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main effects and interactions of 5-HTTLPR with childhood adversities (CHA), recent life events (RLE) and subtypes of recent life events on lifetime suicide attempts (SUIC), current suicidal ideation (BSI03 Thoughts of ending your life), current hopelessness (BSI18 Feeling hopeless about the future), and current thoughts of death (BSI21 Thoughts about death and dying). Of the main effect and interaction effects investigated in the present study, 5-HTTLPR had a signifcant main effect on current suicidal ideation (BSI03 Thoughts of ending your life) in the dominant model, and significantly interacted with recent relationship problems on current suicidal ideation (BSI03 Thoughts of ending your life) in the dominant and on current thoughts about death (BSI21 Thoughts about death or dying) in the dominant and additive models. In all cases, presence of the short allele was associated with higher scores. Solid lines indicate main effects, dashed lines with “X” indicate interaction effects; significant effects are indicated by bold lines and significant Q values are shown in bold type. CHA, childhood adversities; SUIC, lifetime suicide attempts; RLE, recent life events; social, recent social network stressors; financial, recent financial hardships; relationship, intimate relationship problems; personal, recent personal problems; current suic, current suicidal risk markers; BSI03, Thoughts of ending your life; BSI18, Feeling hopeless about the future; BSI21, Thoughts about death and dying.