Figure 4.

Predicted upstream regulators of DEG for embryo survival to day 30. NFKB1, PPARG, and mIR-30c-5p were predicted to be upregulated in embryos that survived to day 30 while KDM5A was predicted to be inhibited. Genes in red were upregulated in embryos that survived to day 30 and genes in green were downregulated. Orange lines represent relationships that lead to activation, blue lines represent relationships that lead to inhibition, yellow lines represent relationships inconsistent with the predicted state, and gray lines represent situations where the effect is not predicted.