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Comparison of Receiver Operating Characteristic Curves for Serum AFP, let-7a-1, and Combination of both in Cirrhosis Versus HCV Group
| Variable | Cut off | Sensitivity | Specificity | PVP | PVN | DA |
|---|---|---|---|---|---|---|
| AFP | 10 ng/ml | 70% | 100% | 100% | 76.9% | 85% |
| Let-7a-1 | ≥1.5 | 75% | 70% | 71.4% | 73.7% | 72.5% |
| AFP + Let-7a-1 |
One positive of two | 95% | 100% | 95% | 95.2% | 95% |
PVP, Predictive value of positive; PVN, Predictive value of negative; DA, Diagnostic accuracy.
