Table 4.

Clinical Description of BRCA1 5382insC Mutation Carriers

	Carrier 1	Carrier 2	Carrier 3	Carrier 4
Age of first presentation (years)	40	32	48	41
Menopausal state	Premenopause	Premenopause	Premenopause	Premenopause
	Sister BC	Sister BC died	MotherBC died	Mother BC
Family history	Father brain	Aunt BC died	Aunt bilateral BC	Aunt BC
	Brother lung	Uncle GIT		Sister BC
Mammography	BIRADS IV	BIRADS V	BIRADS IV	BIRADS V
Pathology	IDC	IDC	IDC	IDC
Cancer stage	III	III	II	IV
Visceral metastasis	Free	Free	Free	Free
Bone metastasis	Free	Free	Free	Positive
Hormone receptors and HER2 status	ER, PR -ve	ER, PR +ve	ER, PR +ve	ER, PR +ve
	HER2 +ve	HER2 -ve	HER2 -ve	HER2 -ve
	HER2 enriched	Luminal A	Luminal A	Luminal A
Survival	Still alive	Still alive	Still alive	Still alive

BIRADS, Breast Imaging; Reporting and Data System IDC, Infiltrating ductal carcinoma; ILC, Invasive lobular carcinoma; DCIS, Ductal carcinoma in situ; ER, Estrogen receptors; PR, Progesterone receptors; HER2, The human epidermal growth factor receptor 2; BRCA1, Breast cancer gene 1