Table 2.
Genotype Analysis and Allele Frequencies of TNF-α and TNF-β Gene in Breast Cancer Patients and Healthy Controls
| Genotype | Patients N=150 | Control N=300 | p-value | OR (95%CI) |
|---|---|---|---|---|
| TNF-α (-308) (rs1800629G>A) | ||||
| GG | 68 (45.3) | 207 (69.0) | <0.0001 | 0.37 (0.24-0.55) |
| GA | 73 (48.6) | 80 (26.6) | <0.0001 | 2.60 (1.73-3.92) |
| AA | 9 (6.0) | 13 (4.3) | 0.4887 | 1.40 (0.58-3.37) |
| G Allele | 209 (69.66) | 494 (82.3) | <0.0001 | 0.49 (0.35-0.68) |
| A Allele | 91 (30.33) | 106 (17.66) | <0.0001 | 2.02 (1.46-2.80) |
| TNF-β (+252) (rs361525 A>G) | ||||
| AA | 86 (57.3) | 155 (38.33) | 0.2712 | 1.25 (0.84-1.86) |
| AG | 56 (37.3) | 118 (39.33) | 0.7581 | 0.91 (0.61-1.37) |
| GG | 8 (5.3) | 27 (9.0) | 0.195 | 0.56 (0.25-1.28) |
| A Allele | 228 (76) | 428 (71.33) | 0.1523 | 1.27 (0.92-1.75) |
| G Allele | 72 (24) | 172 (28.66) | 0.1523 | 0.78 (0.57-1.08) |