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. 2010 Nov 18:739–1128. doi: 10.1016/B978-0-12-249951-7.50015-8

Figure 3.

Figure 3

Genome organization in coronaviruses. ORFs are represented by boxes and indicated by numbers in, below or above the box except for the SARS CoV ORF 1a and 1b (see below). The names below or on top of the bars indicate the protein encoded by the corresponding ORF. The structural protein genes are marked by various symbols while the proteins of the nonstructuralgenesare not designated. The 5′ leader sequence is depicted by a small black box. Protein acronyms are as in figure 2. Δ, deleted. nsp, non-structural protein. The arrow between ORF 1a and 1b represents the ribosomal frameshifting site. HCoV-OC43 does not have the two non-structural proteins encoded by gene 4. The translation products of ORFs MHV 5a, BCoV 4a,b, FCoV and CCoV 3b have not been detected. ORFs TGEV 3b, FCoV and CCoV 3c, and HCV229E 3a,b are homologous. The 3a ORFs of TGEV, FCoV and CCoV are homologous. ORFs TGEV 7 and the 7a of FCoV and CCoV are homologous. Genetic structure of SARS-CoV: the numbers above ORF 1a and 1b indicate the putative proteolytic cleavage products; the red arrowheads depict the papain-like cysteine protease cleavage sites and the blue arrowheads represent the 3C-like cysteine protease cleavage sites.